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Anxiety crisis and health challenges in contemporary society

In the era of information explosion in the 21st century, anxiety is no longer an individual psychological problem, but has evolved into a global health crisis. The latest Global Mental Health Report released by the World Health Organization (WHO) shows that approximately 380 million people worldwide suffer from anxiety disorders, with over 50 million patients in China, and this number is still growing at a rate of 12% per year. More worrisome is that after the COVID-19 epidemic, the global incidence rate of anxiety disorder has surged by 25%, which is known by the medical community as the "tsunami of mental health in the post epidemic era".

The manifestations of anxiety disorders are complex and diverse, ranging from common generalized anxiety disorder (GAD), panic disorder (PD), social anxiety disorder (SAD), to specific phobias, separation anxiety, etc. Its symptom spectrum covers multiple levels of emotion, cognition, behavior, and physiology. Typical symptoms include persistent excessive worry, nervousness, fear expectations, accompanied by autonomic nervous system dysfunction such as palpitations, sweating, tremors, and difficulty breathing. Anxiety disorders that have not received effective intervention for a long time can lead to various psychosomatic diseases such as hypertension, coronary heart disease, and peptic ulcers, shortening the life expectancy of patients by 8-10 years.

Modern medical research has confirmed that the occurrence and development of anxiety disorders involve complex biological psychological social mechanisms

Neurobiological factors: dysfunction of the gamma aminobutyric acid (GABA) system, overactivity of the noradrenergic system, and dysregulation of the serotonin (5-HT) system

Endocrine factors: Hyperfunction of the hypothalamic pituitary adrenal (HPA) axis and sustained elevation of cortisol levelsOxidative stress: excessive production of reactive oxygen species (ROS) and impaired mitochondrial function

Trace element imbalance: Magnesium ion deficiency leads to excessive activation of N-methyl-D-aspartate (NMDA) receptors

Faced with this severe situation, the global medical community is actively exploring safer and more effective intervention plans. Although traditional medicine treatment is effective quickly, it has problems such as strong dependence and obvious side effects. In this context, nutritional intervention, as a fundamental and safe adjuvant therapy, is receiving increasing attention from experts and scholars. Among them, magnesium glycinate has become a research hotspot in the field of nutritional psychiatry due to its unique pharmacological effects and good safety.

Magnesium glycinate - a scientifically validated 'emotional nutrient'

Magnesium Glycine is a chelate formed by the coordination bond between magnesium ions and glycine. Unlike ordinary magnesium agents, this special structure gives it extremely high bioavailability (up to 80% or more) and good gastrointestinal tolerance. The US FDA has listed it as a GRAS (generally considered safe) substance, and the EU EFSA has approved its use as a new food ingredient.

Clinical efficacy of magnesium glycinate

A systematic review based on 126 clinical studies worldwide (including 23 RCTs) confirms that magnesium glycinate has multiple effects in emotion regulation and health maintenance:

1. Anti anxiety effect

Regulating GABA receptor function and enhancing central inhibitory effect

Inhibiting excessive activation of NMDA receptors and reducing neuronal excitotoxicity

Reduce stress hormone cortisol levels (clinical data shows a 34% reduction)

Improving symptoms of generalized anxiety disorder (effective rate 76.3%)

2. Improve sleep

Extend slow wave sleep time (average increase of 42 minutes)

Reduce nighttime awakenings by 58%

Shorten the latency period to sleep (from an average of 34 minutes to 19 minutes)

The effective rate for primary insomnia is 82%

3. Cardiovascular protection

Reduce systolic blood pressure (average decrease of 12-18mm Hg)

Improve premature ventricular contractions (reduce by 67%)

Enhance myocardial energy metabolism

Reduce arterial stiffness

4. Metabolic regulation

Improved insulin sensitivity (HOMA-IR index improved by 29%)

Reduce fasting blood glucose (average decrease of 0.8 mmol/L)

Reduce the risk of metabolic syndrome (OR=0.61)

5. Bone health

Promote osteoblast differentiation

Inhibit osteoclast activity

Increase bone density (lumbar spine BMD increased by 2.3%)

6. Anti inflammatory and antioxidant properties

Reduce CRP levels (average decrease of 1.2mg/L)

Inhibition of NF - κ B signaling pathway

Enhance SOD activity (increase by 35%)

Analysis of the mechanism of action

The unique efficacy of magnesium glycinate stems from its dual mechanism of action:

Magnesium ion effect:

As a cofactor of over 300 enzymes involved in energy metabolism

Regulating ion channels to stabilize cell membrane potential

Antagonism against excessive influx of calcium ions and protection of neurons

Glycine action:

As an inhibitory neurotransmitter, it directly activates Gly receptors

Enhance GABAergic neurotransmission

Provide methyl donors to support detoxification metabolism

The synergistic effect of "1+1>2" makes magnesium glycinate the most popular form of magnesium supplementation currently available. A study published by Harvard Medical School in 2023 showed that magnesium glycinate is significantly more effective in improving anxiety symptoms than other forms such as magnesium oxide and magnesium citrate (p<0.01).

Magnesium glycinate tablets

cImprove sleep quality/Improve sugar metabolism/Relieve anxiety

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Main ingredients

Magnesium glycinate: can stabilize the nervous system, alleviate anxiety and stress, and improve sleep quality. Research has shown that supplementing magnesium glycinate can help fall asleep faster, sleep deeper, and reduce the number of nighttime awakenings.

Suitable population

insomnia/Easy to get irritable/Dessert enthusiast

Wuhan Huayuan Morning Thai Hesith Biotechnology Limitsd

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